Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.
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A reaction pattern in follicular epithelium. Therapeutic options and efficacy are based on retrospective case series or anecdotal reports; no controlled trials exist.
This condition of the skin appendages article is a stub.
Pseudopelade of Brocq Central centrifugal cicatricial alopecia Pressure alopecia Traumatic alopecia Tumor alopecia Hot comb alopecia Perifolliculitis capitis abscedens et suffodiens Graham-Little syndrome Folliculitis decalvans ungrouped: The patient completed all six doses of ROM, and has not had recurrence in the ensuing 1 year.
Home About Us Advertise Amazon. Dapsone has been reported to clear Follicular mucinosis and the presence of dapsone in the MDT alopeia be the agent responsible for healing in cases 1 and 2.
Wlopecia between follicular keratinocytes.
Retrieved from ” https: Body odor Chromhidrosis Fox—Fordyce disease. However, monoclonality does not distinguish lymphoma-associated FM from idiopathic FM. Minocycline has been used in treatment of Alopecia Mucinosa, and minocycline in ROM may be the responsible for healing in case 3: A clinical diagnosis of leprosy was considered and she was asked to apply a moisturizing cream and kept under observation as a biopsy was refused.
Familial reticuloendotheliosis with eosinophilia and follicular mucinosis. Accumulation of mucin, which is composed of hyaluronate and sulfated glycosaminoglycans, in the follicle results in disruption of cellular attachments and destruction of the pilosebaceous subunit. Of note, FM may resolve spontaneously. Consider if patient is intolerant or unresponsive to first-line agents.
Isotretinoin is pregnancy category X. FM has been reported as an incidental finding in a variety of inflammatory skin disorders, such as acne, insect bite reactions, and lichen planus. On hair-bearing skin e. He too responded completely within 3 months with rifampicin, ofloxacin, minocycline ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year.
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Follicular Mucinosis and Alopecia Mucinosa. Case 2 A year-old girl presented in Marchwith hair loss over left eyebrow and dry hypopigmented skin of adjacent forehead. The T-lymphocyte, the mucinosis epithelial interstitium and immunostimulation. In alopwcia subtype of FM, lesional skin polymerase chain reaction PCR based molecular testing for T-cell clonality may be positive, thereby suggesting mucinoss of the infiltrating T lymphocytes.
Inflammatory diseases of hair follicles, sweat glands and cartilage; pp.
Therefore it is too much of coincidence to consider that the response in all patients was due to natural remission, and it is most likely that it was the oral treatment that brought about healing of the lesions. Conditions of the skin appendages Mucinoses Condition of the skin appendages stubs. Infobox medical condition new All stub articles. In patches of early leprosy granulomas may be absent and lymphocytes may be seen infiltrating the epidermis and follicular epithelium and arrector pilorum muscles.
The etiology is not known. Powered By Decision Support in Medicine. Analysis of lesional skin for T-cell clonality using PCR for T cell receptor[TCR] gene rearrangements should be considered in patients with known or suspected FM, but is not required for diagnosis.
Minocycline mg orally, twice daily; response noted within 6 months; begin to taper slowly over months after lesions have cleared.
Introduction What was known? The presence of intrafollicular mucin can be confirmed with colloidal iron tissue stains. In this article we describe three cases, two children with a single facial lesion clinically suspected to be leprosy in whom biopsy showed follicular mucinosis without granulomas.
Secondary alopecia mucinosa should be mucijosa appropriately for the underlying skin disease, particularly if it is cutaneous T-cell lymphoma.
Follicular Mucinosis (Alopecia Mucinosa)
Alopecia mucinosa most commonly affects face, neck and scalp, but any part of the body may be affected. It is possible that these activated T lymphocytes may cause mucin accumulation in the affected follicles, and it is conceivable that follicular mucinosis may occur in lesions of leprosy without granulomas. Perioral dermatitis Granulomatous perioral dermatitis Phymatous rosacea Rhinophyma Blepharophyma Gnathophyma Metophyma Otophyma Papulopustular rosacea Lupoid rosacea Erythrotelangiectatic rosacea Glandular rosacea Gram-negative alopeia Steroid rosacea Ocular rosacea Persistent edema of rosacea Rosacea conglobata variants Periorificial dermatitis Pyoderma faciale.
With the good response to MDT in the previous 2 cases it was decided to start him also on MDT, however, as he was shortly returning to the USA, he was started on ROM therapy rifampicin mg, ofloxacin mg, minocycline mg to alpoecia taken once a month micinosa 6 months. You must be a registered member of Dermatology Advisor to post a comment.