Mandible / maxilla – Malignant tumors: ameloblastic fibrosarcoma. A case of an ameloblastic fibrosarcoma in the mandible is described. The primary tumor was seen in a 5-year-old child. In spite of repeated surgical. Introduction. Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent.

Author: Kazishicage Kagal
Country: Bahamas
Language: English (Spanish)
Genre: Education
Published (Last): 26 March 2018
Pages: 235
PDF File Size: 18.32 Mb
ePub File Size: 8.96 Mb
ISBN: 688-7-64628-167-8
Downloads: 7805
Price: Free* [*Free Regsitration Required]
Uploader: Gulkree

Odontogenic tumors and tumor-like lesions constitute a rare group of heterogeneous diseases that range from nonneoplastic tissue proliferations to malignant tumors with metastatic potential. Intraoral view shows buccal and palatal expansion in the left maxillary region and the exophytic ulcerated mass. Open in a separate window. Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: The differential diagnosis includes other ameloblaatic sarcomas, ameloblastic carcinosarcoma and spindle cell carcinoma.

Journal List Case Rep Pathol v. Support Center Support Center. Abstract Ameloblastic fibrosarcoma is an sarcima odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life.

Pathology Outlines – Malignant tumors: ameloblastic fibrosarcoma

Malignant odontogenic tumors are classified as odontogenic carcinomas and odontogenic sarcomas [ 1 ]. Author information Article notes Copyright and License information Disclaimer. He performed an incisional biopsy and sent it to a general pathology service for histopathologic examination.


Left half of mandible. Ameloblastic fibrosarcoma of the mandible: World Health Organization Classification of Tumours: Written informed consent was obtained from the patient for publication of this case report and the accompanying images.

Experimental and Therapeutic Medicine. The patient underwent a left hemimandibular resection and immediate fibular free flap reconstruction. Click here for patient related inquiries. Diagnosis dependent on clinical, radiologic and pathologic correlation.

The final histopathological diagnosis was identical to that of the incisional biopsy and an AFS was confirmed. Received Jan 11; Accepted Mar 2. Page views in Panoramic radiographs demonstrated an ill-defined unilocular radiolucent lesion in the left posterior region of maxilla and the left maxillary sinus was totally obliterated.

The majority fibgo reported ameloblwstic have been found in the posterior region of mandible and rarely maxillary involvement is indicated.

Treatment of choice is wide surgical excision, with long-term follow-up.

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures Figure 2. Ameloblastic fibrosarcoma of the jaws – sacoma of three cases.

Patients often present with swelling and pain Occasionally painless facial mass with accompanying paresthesia. Biphasic with benign epithelium and malignant stroma: Zarcoma, also considering epithelial component, the diagnosis based on histopathological examination was not a serious problem.


Ameloblastic fibrosarcoma of the mandible: Intraoral examination and a CT scan evaluation b revealed no evidence of recurrence after two years. They are derived from epithelial, ectomesenchymal, and mesenchymal elements of the tooth-forming apparatus.

Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up

Radiographically, AFS usually appears as an expansile destructive radiolucency with ill-defined margins. The malignant spindle cell proliferation showed positive staining with p and a high proliferation index with ki The prognosis associated with AFS is good gibro treated with surgical resection [ 4 ]. This article has been cited by other articles in PMC.

Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: Computed tomography scan showed extension of the lesion medially and vertically to the nasal septal bone and the inferior orbital rim, respectively [ Figure 2 ].

A year-old female presented with one month history of right mandibular mass.

Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. Discussion AFS was first reported by Heath in describing it as a spindle cell sarcoma that also had epithelial cells resembling the cells of the enamel organ [ 5 ].